BLM Polyclonal Antibody

The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3'-5' helicase activity. The normal protein may act to suppress inappropriate recombination.

The BLM Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of Bloom syndrome protein (BLM) in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human BLM protein, followed by affinity purification using a BLM-specific antigen. The resulting polyclonal antibody exhibits excellent specificity and sensitivity towards BLM protein, with minimal cross-reactivity to other proteins.

The BLM Polyclonal Antibody is suitable for a wide range of applications, including Western blotting, immunoprecipitation, immunofluorescence, and ELISA. It has been extensively validated in various cell lines and tissues, and has been shown to detect endogenous BLM protein in human cells. This antibody is also compatible with a variety of detection methods, including chemiluminescence, fluorescence, and colorimetric assays.

In summary, the BLM Polyclonal Antibody is a reliable and versatile tool for the detection and quantification of BLM protein in biological samples. Its high specificity and sensitivity make it an ideal choice for researchers studying the role of BLM in DNA repair, genome stability, and cancer biology.