BMAL1 (Acetyl Lys538) Polyclonal Antibody

The protein encoded by ARNTL is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in ARNTL have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for ARNTL.

Introducing the BMAL1 (Acetyl Lys538) Polyclonal Antibody, a cutting-edge scientific tool designed to facilitate advanced research in the field of circadian rhythm regulation. This high-quality antibody is meticulously developed using state-of-the-art techniques to ensure exceptional specificity and sensitivity.

The BMAL1 (Acetyl Lys538) Polyclonal Antibody is specifically designed to target the acetylated lysine 538 residue of the BMAL1 protein, a key component of the circadian clock machinery. By selectively recognizing this acetylation site, researchers can gain valuable insights into the intricate molecular mechanisms underlying circadian rhythm regulation.

This polyclonal antibody exhibits outstanding performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. Its exceptional specificity guarantees minimal cross-reactivity, enabling accurate and reliable detection of the acetylated BMAL1 protein in complex biological samples.

The BMAL1 (Acetyl Lys538) Polyclonal Antibody is manufactured using rigorous quality control measures to ensure batch-to-batch consistency and reproducibility. Each lot is thoroughly validated to meet the highest standards of performance, guaranteeing reliable and reproducible results in every experiment.

With its superior sensitivity, this antibody allows for the detection of low-abundance acetylated BMAL1 protein, even in samples with limited starting material. Its robust performance ensures optimal signal-to-noise ratios, enabling precise quantification and analysis of circadian clock dynamics.

In summary, the BMAL1 (Acetyl Lys538) Polyclonal Antibody is an indispensable tool for researchers investigating circadian rhythm regulation. Its exceptional specificity, sensitivity, and reliability make it an ideal choice for a wide range of applications. Trust in this cutting-edge antibody to unlock the secrets of the circadian clock and advance scientific understanding in this fascinating field.