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BT Lab

SKU(재고 관리 코드):BT-AP00914

BMAL1 Polyclonal Antibody

BMAL1 Polyclonal Antibody

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Aryl hydrocarbon receptor nuclear translocator-like protein 1 encoded by ARNTL is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene.

The BMAL1 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of BMAL1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human BMAL1 protein. The resulting polyclonal antibody has been purified using protein A affinity chromatography and validated for its specificity and sensitivity in Western blotting, immunohistochemistry, and immunofluorescence assays.

The BMAL1 Polyclonal Antibody is a valuable tool for researchers studying the circadian clock and its regulation. BMAL1 is a key component of the circadian clock and plays a critical role in regulating the expression of clock-controlled genes. This antibody can be used to investigate the expression and localization of BMAL1 in various tissues and cell types, as well as to study the effects of different stimuli on BMAL1 expression and activity.

The BMAL1 Polyclonal Antibody is supplied as a liquid in phosphate-buffered saline (PBS) containing 0.02% sodium azide as a preservative. It is available in different sizes to meet the needs of different applications. This antibody is suitable for use in a variety of research applications, including Western blotting, immunohistochemistry, and immunofluorescence. It is recommended to use this antibody at a dilution of 1:1000 for Western blotting and 1:200 for immunohistochemistry and immunofluorescence.

In summary, the BMAL1 Polyclonal Antibody is a high-quality antibody that provides reliable and accurate detection of BMAL1 protein in various biological samples. It is an essential tool for researchers studying the circadian clock and its regulation, and it is suitable for use in a variety of research applications.

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