BMP-8 Polyclonal Antibody

BMP8B (bone morphogenetic protein 8b) encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of BMP8B may be downregulated in pancreatic cancer. BMP8B may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1.

The BMP-8 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of BMP-8 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human BMP-8 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards BMP-8 protein, making it an ideal tool for various research applications.

The BMP-8 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various assays, including Western blotting, immunohistochemistry, and ELISA. It has been shown to detect BMP-8 protein in a variety of tissues and cell types, including bone, cartilage, muscle, and adipose tissue. This antibody has also been used to study the role of BMP-8 in various physiological and pathological processes, such as bone formation, muscle regeneration, and cancer.

The BMP-8 Polyclonal Antibody is supplied as a purified IgG fraction, which has been affinity-purified from rabbit serum. It is provided in a liquid form, which can be easily diluted and used for various applications. This antibody is suitable for use in both research and diagnostic applications, and it is compatible with a wide range of detection systems.

In summary, the BMP-8 Polyclonal Antibody is a highly specific and sensitive antibody that is ideal for the detection of BMP-8 protein in various biological samples. It has been extensively validated for its specificity and sensitivity, and it is suitable for use in various research and diagnostic applications.