BRCA1 Polyclonal Antibody

BRCA1encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein (BRCA1, DNA repair associated) combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

The BRCA1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of BRCA1 protein expression in various biological samples. This antibody is produced using a polyclonal approach, ensuring a diverse range of epitope recognition and enhanced sensitivity.

With its exceptional affinity and specificity, the BRCA1 Polyclonal Antibody enables accurate and reliable identification of BRCA1 protein in Western blotting, immunohistochemistry, and immunofluorescence applications. It exhibits minimal cross-reactivity with other proteins, ensuring precise and unambiguous results.

The BRCA1 Polyclonal Antibody is manufactured using state-of-the-art techniques and undergoes rigorous quality control measures to ensure consistent performance and reproducibility. It is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation.

This antibody is suitable for use in both research and clinical settings, aiding in the investigation of BRCA1 protein expression patterns and its role in various physiological and pathological processes. Its versatility and reliability make it an indispensable tool for scientists and clinicians working in the fields of cancer research, genetic testing, and personalized medicine.

Choose the BRCA1 Polyclonal Antibody for its exceptional sensitivity, specificity, and reliability, and unlock new insights into the intricate mechanisms of BRCA1 protein function.