BRCA1 Polyclonal Antibody

BRCA1encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein (BRCA1, DNA repair associated)combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes.

This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

The BRCA1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of BRCA1 protein expression in various biological samples. This antibody is produced through a rigorous process, ensuring its high quality and reliability.

The BRCA1 Polyclonal Antibody exhibits exceptional affinity towards the BRCA1 protein, enabling accurate and precise identification of this crucial biomarker. Its polyclonal nature allows for enhanced sensitivity, enabling the detection of even low levels of BRCA1 protein expression.

This antibody is suitable for a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively validated and proven to deliver consistent and reproducible results across different experimental conditions.

With its exceptional performance and reliability, the BRCA1 Polyclonal Antibody is an indispensable tool for researchers and clinicians involved in cancer research, genetic testing, and personalized medicine. Its ability to accurately detect and quantify BRCA1 protein expression makes it an invaluable asset in understanding the role of BRCA1 in various biological processes and diseases.

Choose the BRCA1 Polyclonal Antibody for its exceptional quality, sensitivity, and versatility, and unlock new insights into the intricate mechanisms underlying BRCA1-associated disorders.