c-Abl(Phospho-Tyr412) Rabbit Polyclonal Antibody

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes| including cell division| adhesion| differentiation| and response to stress. The activity of the protein is negatively regulated by its SH3 domain| whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation| suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias| most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants| which contain alternative first exons that are spliced to the remaining common exons.

The c-Abl(Phospho-Tyr412) Rabbit Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of c-Abl protein phosphorylated at tyrosine 412. This antibody has been rigorously validated for use in various applications, including Western blotting, immunoprecipitation, and immunofluorescence.

The c-Abl protein is a non-receptor tyrosine kinase that plays a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis. Phosphorylation of c-Abl at tyrosine 412 is known to regulate its activity and downstream signaling pathways.

This rabbit polyclonal antibody has been developed using state-of-the-art techniques and exhibits high affinity and specificity towards the phosphorylated form of c-Abl at tyrosine 412. It has been extensively tested and validated to ensure reliable and reproducible results.

The c-Abl(Phospho-Tyr412) Rabbit Polyclonal Antibody is supplied as a liquid formulation in a convenient size of 100 µg. It is provided in a ready-to-use format, eliminating the need for any additional preparation steps. The antibody is suitable for use in various experimental settings and has been cited in numerous scientific publications.

With its exceptional sensitivity and specificity, the c-Abl(Phospho-Tyr412) Rabbit Polyclonal Antibody is an indispensable tool for researchers studying the role of c-Abl phosphorylation in cellular processes and disease mechanisms. Its reliable performance and ease of use make it an ideal choice for both basic research and drug discovery applications.