c-Abl Polyclonal Antibody

ABL1 is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM: 151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons.

The c-Abl Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of c-Abl protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and sensitivity.

The c-Abl Polyclonal Antibody exhibits exceptional performance in a wide range of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes both the phosphorylated and non-phosphorylated forms of c-Abl, enabling comprehensive investigation of its activation status.

With its superior specificity, this antibody guarantees minimal cross-reactivity with other proteins, ensuring accurate and precise results. Its robust and consistent performance makes it an ideal choice for researchers and scientists working in the fields of cancer biology, signal transduction, and drug discovery.

The c-Abl Polyclonal Antibody is supplied in a convenient and ready-to-use format, allowing for immediate application in experiments. It is available in various sizes to accommodate different experimental needs. Each batch of this antibody undergoes rigorous quality control procedures to ensure batch-to-batch consistency and reliability.

Choose the c-Abl Polyclonal Antibody for its exceptional quality, reliability, and versatility, and unlock new insights into the role of c-Abl in cellular processes and disease mechanisms.