CA VIII Polyclonal Antibody

The protein encoded by CA8 (carbonic anhydrase 8) was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e. The reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in CA8 are associated with cerebellar ataxia, mental retardation, and dysequilibrium syndrome 3 (CMARQ3). Polymorphisms in CA8 are associated with osteoporosis, and overexpression of CA8 in osteosarcoma cells suggests an oncogenic role. Alternative splicing results in multiple transcript variants.

The CA VIII Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of Carbonic Anhydrase VIII (CA VIII) protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human CA VIII protein. The resulting polyclonal antibody exhibits high affinity and specificity towards CA VIII protein, making it an ideal tool for various research applications.

The CA VIII Polyclonal Antibody is suitable for use in various immunoassays, including Western blotting, immunohistochemistry, and ELISA. It has been validated for use in human, mouse, and rat samples, and has been shown to detect CA VIII protein in a variety of tissues, including brain, kidney, and liver. This antibody is supplied as a purified IgG fraction, and has been tested for its specificity and sensitivity in various applications.

In summary, the CA VIII Polyclonal Antibody is a reliable and effective tool for the detection and quantification of CA VIII protein in various biological samples. Its high specificity and sensitivity make it an ideal reagent for researchers studying the role of CA VIII in various physiological and pathological processes.