Cadherin-18 Polyclonal Antibody

CDH18 encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for CDH18.

The Cadherin-18 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Cadherin-18 protein expression in various biological samples. This antibody is produced using advanced immunization techniques, ensuring high affinity and sensitivity towards Cadherin-18.

Cadherin-18 is a calcium-dependent cell adhesion molecule that plays a crucial role in cell-cell adhesion and tissue morphogenesis. It is primarily expressed in epithelial tissues, including lung, kidney, and gastrointestinal tract. Dysregulation of Cadherin-18 has been implicated in various pathological conditions, such as cancer metastasis and tissue remodeling.

The Cadherin-18 Polyclonal Antibody exhibits exceptional specificity, enabling precise identification and localization of Cadherin-18 in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting applications. It recognizes both the full-length and cleaved forms of Cadherin-18, allowing comprehensive analysis of protein expression and processing.

This antibody is manufactured under stringent quality control measures, ensuring batch-to-batch consistency and reproducibility. It has been extensively validated in various experimental settings, demonstrating excellent performance and reliability. The Cadherin-18 Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation.

With its exceptional specificity, sensitivity, and reliability, the Cadherin-18 Polyclonal Antibody is an indispensable tool for researchers and scientists involved in studying Cadherin-18 biology and its implications in various physiological and pathological processes.