Cadherin-23 Polyclonal Antibody

CDH23 (cadherin related 23) is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. CDH23 is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of CDH23 may also be associated with breast cancer. Alternative splice variants encoding different isoforms have been described.

The Cadherin-23 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Cadherin-23 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Cadherin-23 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Cadherin-23 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to specifically recognize Cadherin-23 protein in various tissues, including the inner ear, retina, and kidney. This antibody is suitable for use in both research and diagnostic applications.

The Cadherin-23 Polyclonal Antibody is a valuable tool for researchers studying the function and regulation of Cadherin-23 protein in various biological processes. It can be used to investigate the role of Cadherin-23 in hearing and vision, as well as in the development and maintenance of the kidney. This antibody is also useful for diagnostic applications, such as the detection of Cadherin-23 protein in patient samples for the diagnosis of certain diseases.

Overall, the Cadherin-23 Polyclonal Antibody is a high-quality and reliable antibody that is ideal for the detection of Cadherin-23 protein in various biological samples. Its specificity and sensitivity make it a valuable tool for both research and diagnostic applications.