Cadherin-8 Polyclonal Antibody

CDH8 encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance.

The Cadherin-18 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Cadherin-18 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Cadherin-18 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Cadherin-18 Polyclonal Antibody has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to specifically recognize Cadherin-18 protein in human, mouse, and rat tissues, making it a versatile tool for researchers studying the role of Cadherin-18 in various biological processes.

This antibody is highly sensitive, with a detection limit of 0.1 ng/mL, and exhibits minimal cross-reactivity with other proteins, ensuring accurate and reliable results. It is also highly specific, with no detectable binding to other Cadherin family members, further enhancing its utility in research applications.

In summary, the Cadherin-18 Polyclonal Antibody is a high-quality, reliable, and specific tool for the detection of Cadherin-18 protein in various biological samples. Its versatility and sensitivity make it an ideal choice for researchers studying the role of Cadherin-18 in various biological processes.