Calpain 10 Polyclonal Antibody

Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. CAPN10 encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. CAPN10 is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene.

The Calpain 10 Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Calpain 10 protein in various biological samples. This antibody has been meticulously developed using advanced techniques to ensure exceptional sensitivity and specificity.

Calpain 10 is a calcium-dependent cysteine protease that plays a crucial role in various cellular processes, including signal transduction, cytoskeletal remodeling, and apoptosis. Dysregulation of Calpain 10 has been implicated in the pathogenesis of several diseases, such as diabetes, obesity, and cancer. Therefore, accurate detection and quantification of Calpain 10 protein levels are of utmost importance in understanding its functional significance and potential therapeutic implications.

The Calpain 10 Polyclonal Antibody exhibits outstanding performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes the native and denatured forms of Calpain 10 protein, ensuring reliable and reproducible results across different experimental conditions.

This antibody has been rigorously validated using a wide range of samples, including human, mouse, and rat tissues, ensuring its broad applicability across different species. It exhibits minimal cross-reactivity with other related proteins, ensuring specific detection of Calpain 10 without any interference from non-specific binding.

The Calpain 10 Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is provided in a convenient format, allowing for easy storage and handling.

In summary, the Calpain 10 Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of Calpain 10 protein. Its exceptional sensitivity, broad applicability, and ease of use make it an indispensable asset for researchers and scientists studying the functional role of Calpain 10 in various biological processes and disease pathogenesis.