CaMKK2 Polyclonal Antibody

The product of CAMKK2 belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of CAMKK2 plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases.

The CaMKK2 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of CaMKK2 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human CaMKK2 protein. The antibody has been purified using protein A affinity chromatography and is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The CaMKK2 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in detecting CaMKK2 protein in various biological samples. It has been shown to detect endogenous CaMKK2 protein in human and mouse tissues, including brain, heart, liver, and kidney. The antibody has also been shown to detect CaMKK2 protein in various cell lines, including HEK293, COS-7, and NIH/3T3 cells.

The CaMKK2 Polyclonal Antibody is a valuable tool for researchers studying the role of CaMKK2 in various biological processes, including cell signaling, metabolism, and gene expression. It can be used to investigate the expression and localization of CaMKK2 protein in different tissues and cell types, as well as to study the regulation of CaMKK2 activity by various stimuli.

In summary, the CaMKK2 Polyclonal Antibody is a highly specific and sensitive antibody that is suitable for use in various applications. It has been extensively validated for its specificity and sensitivity in detecting CaMKK2 protein in various biological samples and is a valuable tool for researchers studying the role of CaMKK2 in various biological processes.