Caspase-1 Polyclonal Antibody

CASP1 encodes a protein (caspase 1) which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

The Caspase-1 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of Caspase-1 protein in various biological samples. This antibody has been rigorously tested and validated to ensure its reliability and accuracy in experimental settings.

Caspase-1, also known as interleukin-1 beta-converting enzyme (ICE), plays a crucial role in the inflammatory response and programmed cell death. It is involved in the activation and processing of pro-inflammatory cytokines, such as interleukin-1 beta (IL-1β) and interleukin-18 (IL-18), which are key mediators of immune and inflammatory processes.

The Caspase-1 Polyclonal Antibody has been developed using advanced immunization techniques and exhibits high affinity and specificity towards Caspase-1. It recognizes both the pro-form and the active form of Caspase-1, allowing for comprehensive analysis of its expression and activation status.

This antibody is suitable for various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been optimized for use in both human and animal samples, ensuring its versatility and applicability across different research areas.

The Caspase-1 Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, allowing for easy handling and storage. Each batch of antibody undergoes stringent quality control measures to guarantee consistent performance and reproducibility.

In summary, the Caspase-1 Polyclonal Antibody is a reliable and efficient tool for the detection and analysis of Caspase-1 protein. Its high specificity, sensitivity, and versatility make it an invaluable asset for researchers studying inflammation, cell death, and immune responses.