Caspase-10 B/C Polyclonal Antibody

CASP10 encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in CASP10 are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for CASP10.

The Caspase-10 B/C Polyclonal Antibody is a highly specific and reliable tool designed for the detection and analysis of Caspase-10 B/C protein in various biological samples. This antibody has been extensively validated for its exceptional performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications.

Caspase-10 is a crucial member of the caspase family, playing a pivotal role in the initiation and execution of apoptosis. It is involved in the activation of downstream caspases and the cleavage of various cellular substrates, ultimately leading to programmed cell death. Dysregulation of Caspase-10 has been implicated in numerous pathological conditions, including cancer, autoimmune diseases, and neurodegenerative disorders.

The Caspase-10 B/C Polyclonal Antibody has been meticulously developed using high-quality immunogens, ensuring its specificity and sensitivity towards Caspase-10 B/C protein. It exhibits minimal cross-reactivity with other caspase family members, ensuring accurate and reliable results.

This antibody demonstrates exceptional performance in IHC, enabling precise localization and visualization of Caspase-10 B/C protein in tissue sections. It also exhibits robust staining in IF, allowing for detailed examination of protein expression and subcellular localization. Additionally, the antibody exhibits high sensitivity and specificity in WB, facilitating the detection and quantification of Caspase-10 B/C protein in cell lysates.

The Caspase-10 B/C Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size, ensuring cost-effective and efficient experimentation. The antibody has been rigorously tested and validated to ensure consistent and reproducible results.

In summary, the Caspase-10 B/C Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of Caspase-10 B/C protein. Its exceptional performance in IHC, IF, and WB applications, along with its high sensitivity and specificity, make it an invaluable asset for researchers studying apoptosis, cancer, and other related fields.