Caspase 4 Rabbit Polyclonal Antibody

Catalytic activity:Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.|Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.|PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8.|Belongs to the peptidase C14A family.|Contains 1 CARD domain.|subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers| each one formed by a small and a large subunit.|tissue specificity:Widely expressed| with highest levels in spleen and lung. Moderate expression in heart and liver| low expression in skeletal muscle| kidney and testis. Not found in the brain.|

The Caspase 4 Rabbit Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of caspase 4 protein in various biological samples. This antibody is produced using high-quality rabbit polyclonal antibodies, ensuring excellent performance and reliability.

Caspase 4, also known as caspase-4 or ICH-2, is a member of the caspase family of cysteine proteases. It plays a crucial role in the inflammatory response and is involved in the activation of pro-inflammatory cytokines. The aberrant activation of caspase 4 has been implicated in various diseases, including sepsis, neurodegenerative disorders, and cancer.

The Caspase 4 Rabbit Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various experimental conditions. It exhibits minimal cross-reactivity with other caspase family members, ensuring accurate and reliable results. This antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

With its high affinity and specificity, the Caspase 4 Rabbit Polyclonal Antibody offers researchers a valuable tool for studying the role of caspase 4 in various biological processes and disease states. Its superior performance and reliability make it an essential component of any research project aiming to elucidate the molecular mechanisms underlying caspase 4-mediated signaling pathways.

Order the Caspase 4 Rabbit Polyclonal Antibody today and unlock new insights into the function and regulation of caspase 4 in health and disease.