Cav1.3 Polyclonal Antibody

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, namely alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1D subunit. Several transcript variants encoding different isoforms have been found for this gene.

The Cav1.3 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Cav1.3 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of the human Cav1.3 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Cav1.3 Polyclonal Antibody has been extensively validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to specifically recognize the Cav1.3 protein in various tissues, including brain, heart, and kidney. The antibody has also been shown to be highly sensitive, with a detection limit of 0.1 ng of Cav1.3 protein.

This antibody is an essential tool for researchers studying the role of Cav1.3 in various physiological and pathological processes. It can be used to investigate the expression and localization of Cav1.3 in different tissues and cell types, as well as to study the functional role of Cav1.3 in ion channel regulation and calcium signaling. The Cav1.3 Polyclonal Antibody is a reliable and high-quality reagent that can provide valuable insights into the complex biology of Cav1.3.