Caveolin-1 Polyclonal Antibody

The scaffolding protein (caveolin 1) encoded by CAV1 is the main component of the caveolae plasma membranes found in most cell types. Caveolin 1 links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. CAV1 is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in CAV1 have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.

The Caveolin-1 Polyclonal Antibody is a highly specific and sensitive tool for the detection of Caveolin-1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human Caveolin-1 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards Caveolin-1 protein, making it an ideal reagent for various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The Caveolin-1 Polyclonal Antibody is designed to recognize both the full-length and truncated forms of Caveolin-1 protein, which are known to play important roles in various cellular processes, including signal transduction, lipid metabolism, and membrane trafficking. This antibody has been extensively validated in various cell lines and tissues, and has been shown to exhibit minimal cross-reactivity with other proteins, ensuring accurate and reliable results.

The Caveolin-1 Polyclonal Antibody is supplied as a purified IgG fraction, which has been affinity-purified using a column containing immobilized Caveolin-1 protein. This ensures that the antibody is highly specific and free from contaminants that may interfere with its performance. The antibody is also provided in a convenient format, with various sizes available to suit different experimental needs.

Overall, the Caveolin-1 Polyclonal Antibody is a valuable tool for researchers studying Caveolin-1 protein and its functions in various biological processes. Its high specificity, sensitivity, and versatility make it an ideal reagent for a wide range of applications, and its reliable performance ensures accurate and reproducible results.