CD204 Polyclonal Antibody

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type

The CD204 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of CD204 protein expression in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human CD204 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards CD204 protein, making it an ideal tool for various research applications.

The CD204 Polyclonal Antibody is suitable for use in a variety of immunological techniques, including Western blotting, immunohistochemistry, and flow cytometry. It has been validated for use in human, mouse, and rat samples, and has been shown to detect CD204 protein expression in a variety of tissues and cell types. This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The CD204 Polyclonal Antibody is a valuable tool for researchers studying the role of CD204 in various biological processes, including inflammation, immune response, and cancer. Its high sensitivity and specificity make it an ideal reagent for the detection and quantification of CD204 protein expression in a variety of samples. With its reliable performance and consistent results, the CD204 Polyclonal Antibody is a must-have for any laboratory conducting research in this field.