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ELK Biotechnology
SKU(재고 관리 코드):ES9119
CDA7L Rabbit Polyclonal Antibody
CDA7L Rabbit Polyclonal Antibody
CDA7L Rabbit Polyclonal Antibody
Overview
| Product name: | CDA7L rabbit pAb |
| Applications: | WB;ELISA |
| Recommended Dilutions: | WB 1:500-2000 ELISA 1:5000-20000 |
| Immunogen: | Synthesized peptide derived from human protein . at AA range: 140-220 |
| Storage: | Rabbit |
| Storage: | -20°C/1 year |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 1 mg/ml |
| Observed Band: | 49kD |
| GeneID（Human）: | 55536 |
| Human Swiss-Prot No: | Q96GN5 |
| Cellular localization: | Cytoplasm. Nucleus. Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction. |
| Background: | function:Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.,induction:By MYC overexpression in a concentration dependent manner in neuroblastoma cell line.,miscellaneous:Cells lacking CDCA7L display a reduction of 25-30% of colony formation in medulloblastoma cell lines. CDCA7L overexpression induces colony formation.,subcellular location:Associates with chromatin. Translocates from cytoplasm to nucleus under dexamethasone induction.,subunit:Interacts with MYC and PSIP1.,tissue specificity:Ubiquitous. Overexpressed in medulloblastoma., |
| Species Reactivity: | Human;Rat;Mouse; |
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