CKR-1 Polyclonal Antibody

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p.

The CKR-1 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of CKR-1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human CKR-1 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards CKR-1 protein, making it an ideal tool for various research applications.

The CKR-1 Polyclonal Antibody is suitable for use in a variety of immunoassays, including Western blotting, immunohistochemistry, and ELISA. It has been validated for use in human, mouse, and rat samples, and has been shown to detect CKR-1 protein in a variety of tissues and cell types. This antibody is supplied as a purified IgG fraction, and has been tested for purity and specificity by SDS-PAGE and ELISA.

The CKR-1 Polyclonal Antibody is a valuable tool for researchers studying the role of CKR-1 protein in various physiological and pathological processes. Its high sensitivity and specificity make it an ideal reagent for the detection and quantification of CKR-1 protein in complex biological samples. With its reliable performance and consistent results, the CKR-1 Polyclonal Antibody is a must-have for any laboratory conducting research in this field.