Cleaved-Aggrecan (D369) Polyclonal Antibody

ACAN is a member of the aggrecan/versican proteoglycan family. Aggrecan core protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene.

The Cleaved-Aggrecan (D369) Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of cleaved aggrecan protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the cleavage site of aggrecan protein at position D369. The resulting polyclonal antibody exhibits high affinity and specificity towards the cleaved form of aggrecan protein, making it an ideal tool for research applications in the fields of osteoarthritis, cartilage biology, and connective tissue disorders.

The Cleaved-Aggrecan (D369) Polyclonal Antibody has been extensively validated for its performance in various immunoassays, including Western blotting, immunohistochemistry, and ELISA. It recognizes the cleaved form of aggrecan protein with high sensitivity and specificity, while exhibiting minimal cross-reactivity with other related proteins. This antibody is supplied as a purified IgG fraction, which has been affinity-purified from rabbit serum using a column containing the synthetic peptide immunogen.

The Cleaved-Aggrecan (D369) Polyclonal Antibody is a valuable tool for researchers studying the role of aggrecan protein in cartilage degradation and osteoarthritis. It can be used to detect and quantify the cleaved form of aggrecan protein in various biological samples, including synovial fluid, serum, and tissue extracts. This antibody is also suitable for use in diagnostic assays for the detection of aggrecan degradation products in clinical samples.

In summary, the Cleaved-Aggrecan (D369) Polyclonal Antibody is a highly specific and sensitive immunological reagent that is ideal for the detection and quantification of cleaved aggrecan protein in various biological samples. Its high affinity and specificity make it a valuable tool for researchers studying the role of aggrecan protein in cartilage biology and connective tissue disorders.