This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008],
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Aggrecan (Cleaved-Asp369) Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from Jurkat cells, treated with Etoposide 25uM 60', using Aggrecan (Cleaved-Asp369) Antibody. The lane on the right is blocked with the synthesized peptide.