Cleaved-Factor B Bb (K260) Polyclonal Antibody

CFB (complement factor B) encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. CFB localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in CFB are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of CFB is 421 bp from the 5' end of the gene for complement component 2.

The Cleaved-Factor B Bb (K260) Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of Cleaved-Factor B Bb (K260) protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of Cleaved-Factor B Bb (K260) protein. The resulting polyclonal antibody exhibits high affinity and specificity towards the target protein, making it an ideal tool for various research applications.

The Cleaved-Factor B Bb (K260) Polyclonal Antibody is suitable for use in various immunoassays, including Western blotting, immunohistochemistry, and ELISA. It has been validated for use in human, mouse, and rat samples, and has been shown to exhibit minimal cross-reactivity with other related proteins. This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

In summary, the Cleaved-Factor B Bb (K260) Polyclonal Antibody is a reliable and high-quality reagent that can be used for the detection and quantification of Cleaved-Factor B Bb (K260) protein in various biological samples. Its high specificity and sensitivity make it an ideal tool for researchers studying the role of Cleaved-Factor B Bb (K260) in various physiological and pathological processes.