Cleaved-Integrin  Alpha5 HC (F42) Polyclonal Antibody

The product of ITGA5 belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.

The Cleaved-MMP-12 (G106) Polyclonal Antibody is a highly specific and reliable tool designed for the detection and quantification of cleaved matrix metalloproteinase-12 (MMP-12) in various biological samples. This antibody has been meticulously developed using advanced immunization techniques, resulting in a high affinity and specificity towards the cleaved form of MMP-12.

Matrix metalloproteinase-12, also known as macrophage elastase, plays a crucial role in tissue remodeling and inflammation. The cleaved form of MMP-12 is of particular interest as it is associated with various pathological conditions, including chronic obstructive pulmonary disease (COPD), emphysema, and atherosclerosis. Accurate detection and quantification of cleaved MMP-12 is essential for understanding the underlying mechanisms of these diseases and developing targeted therapeutic interventions.

The Cleaved-MMP-12 (G106) Polyclonal Antibody exhibits exceptional sensitivity and selectivity, enabling precise detection of cleaved MMP-12 even at low concentrations. It has been extensively validated for use in various immunoassays, including Western blotting, immunohistochemistry, and enzyme-linked immunosorbent assays (ELISA). This antibody demonstrates minimal cross-reactivity with other MMP isoforms, ensuring reliable and specific results.

Furthermore, the Cleaved-MMP-12 (G106) Polyclonal Antibody is produced using high-quality materials and stringent quality control measures. Each batch is rigorously tested to ensure consistent performance, reliability, and reproducibility. The antibody is supplied in a convenient format, allowing for easy handling and storage.

In summary, the Cleaved-MMP-12 (G106) Polyclonal Antibody is a valuable tool for researchers and clinicians involved in studying MMP-12-related diseases. Its exceptional sensitivity, specificity, and reliability make it an indispensable asset for accurate detection and quantification of cleaved MMP-12 in various biological samples.