Cleaved-Kininogen-1 HC (K380) Polyclonal Antibody

KNG1 uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.

The Cleaved-Kininogen-1 HC (K380) Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of cleaved-kininogen-1 HC (K380) in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the cleaved-kininogen-1 HC (K380) sequence, and is purified using a combination of protein A and peptide affinity chromatography techniques.

The Cleaved-Kininogen-1 HC (K380) Polyclonal Antibody is suitable for use in a variety of applications, including Western blotting, ELISA, immunohistochemistry, and immunofluorescence. It has been validated for use in human, mouse, and rat samples, and exhibits high specificity and sensitivity with minimal cross-reactivity to other related proteins.

This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is recommended to store the antibody at -20°C for long-term storage, and to avoid repeated freeze-thaw cycles.

Overall, the Cleaved-Kininogen-1 HC (K380) Polyclonal Antibody is a reliable and effective tool for the detection and quantification of cleaved-kininogen-1 HC (K380) in various biological samples, and is suitable for use in a wide range of research applications.