Cleaved-Spectrin  Alpha II (D1185) Polyclonal Antibody

Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. SPTAN1 encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. Spectrin alpha chain non-erythrocytic 1 has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in SPTAN1 are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.

The Cleaved-Spectrin Alpha II (D1185) Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of cleaved-spectrin alpha II protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the cleaved-spectrin alpha II protein sequence. The resulting polyclonal antibody exhibits high affinity and specificity towards the target protein, making it an ideal tool for various research applications.

The Cleaved-Spectrin Alpha II (D1185) Polyclonal Antibody is suitable for use in various immunoassays, including Western blotting, immunohistochemistry, and ELISA. It has been validated for use in human, mouse, and rat samples, and has been shown to exhibit minimal cross-reactivity with other proteins. This antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

Overall, the Cleaved-Spectrin Alpha II (D1185) Polyclonal Antibody is a reliable and effective tool for the detection and quantification of cleaved-spectrin alpha II protein in various biological samples. Its high specificity and sensitivity make it an ideal choice for researchers studying the role of this protein in various physiological and pathological processes.