COL17A1 Polyclonal Antibody

COL17A1 (collagen type XVII alpha 1 chain) encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in COL17A1 are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form.

The COL17A1 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of COL17A1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human COL17A1 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The COL17A1 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes a single band of approximately 180 kDa in Western blot analysis of human skin lysates and shows strong staining of the basement membrane zone in skin tissue sections.

This antibody is suitable for use in research applications related to skin biology, wound healing, and autoimmune diseases. It is also a valuable tool for studying the role of COL17A1 in cancer progression and metastasis. The COL17A1 Polyclonal Antibody is available in various sizes and formats to meet the needs of different research applications. It is a reliable and high-quality reagent that can help researchers advance their understanding of COL17A1 biology.