Cubilin Polyclonal Antibody

Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia.

The Cubilin Polyclonal Antibody is a highly specific and reliable tool designed for the detection and quantification of Cubilin protein in various biological samples. This antibody has been extensively validated for its exceptional performance in immunohistochemistry (IHC), immunofluorescence (IF), and western blotting (WB) applications.

Cubilin, a multifunctional receptor protein, plays a crucial role in the endocytic uptake of various ligands, including vitamin B12 and albumin. It is predominantly expressed in the renal proximal tubules, where it functions as a key component of the megalin-Cubilin complex. Dysregulation of Cubilin expression has been implicated in several pathological conditions, such as renal dysfunction and vitamin B12 deficiency.

The Cubilin Polyclonal Antibody exhibits high affinity and specificity towards Cubilin protein, ensuring accurate and reproducible results. It has been rigorously tested and validated using a wide range of sample types, including human, mouse, and rat tissues. This antibody demonstrates minimal cross-reactivity with other related proteins, ensuring reliable and specific detection of Cubilin.

In IHC applications, the Cubilin Polyclonal Antibody shows excellent staining patterns, enabling precise localization of Cubilin protein within tissues. It exhibits strong and specific immunofluorescent signals, making it an ideal choice for visualizing Cubilin expression in various cell types. Additionally, this antibody performs exceptionally well in western blotting, allowing for the detection of Cubilin protein with high sensitivity and specificity.

The Cubilin Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and complex preparation steps. It is provided in a convenient format, ensuring ease of use and compatibility with various laboratory protocols. This antibody is manufactured under strict quality control standards, guaranteeing batch-to-batch consistency and reliable performance.

In summary, the Cubilin Polyclonal Antibody is a highly reliable and specific tool for the detection and quantification of Cubilin protein. Its exceptional performance in IHC, IF, and WB applications, along with its ease of use and batch-to-batch consistency, make it an invaluable asset for researchers studying Cubilin-related processes and diseases.