eIF2 alpha(Phospho Ser51) Polyclonal Antibody

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation| promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA| EIF2| and GTP. EIF2 is composed of 3 nonidentical subunits| the 36-kD EIF2-alpha subunit (EIF2S1)| the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908)| and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al.| 1987

The eIF2 alpha(Phospho Ser51) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of phosphorylated eIF2 alpha at Ser51. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity for the target antigen.

The eIF2 alpha protein plays a crucial role in the regulation of protein synthesis initiation, and its phosphorylation at Ser51 is a key event in the cellular stress response. This phosphorylation event leads to the inhibition of protein synthesis, allowing the cell to conserve energy and adapt to various stress conditions.

The eIF2 alpha(Phospho Ser51) Polyclonal Antibody is validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been extensively tested and proven to provide reliable and reproducible results.

With its high sensitivity and specificity, this antibody is an essential tool for researchers studying cellular stress response, protein synthesis regulation, and related pathways. It offers a valuable means of investigating the role of eIF2 alpha phosphorylation in various physiological and pathological processes.

The eIF2 alpha(Phospho Ser51) Polyclonal Antibody is supplied in a convenient and ready-to-use format, allowing for easy and efficient experimentation. It is available in different sizes to suit various experimental needs.

Choose the eIF2 alpha(Phospho Ser51) Polyclonal Antibody for its exceptional quality, reliability, and performance, and unlock new insights into the intricate mechanisms of cellular stress response and protein synthesis regulation.