ErbB-4(Phospho Tyr1284) Polyclonal Antibody

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

The ErbB-4(Phospho Tyr1284) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of ErbB-4 protein phosphorylated at Tyr1284. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity for the target protein.

The ErbB-4 receptor tyrosine kinase plays a crucial role in various cellular processes, including cell proliferation, differentiation, and survival. Phosphorylation of Tyr1284 is known to regulate the activation and signaling of ErbB-4, making it an important site for investigation in various research areas, such as cancer biology and signal transduction.

This polyclonal antibody has been rigorously validated for its performance in various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits excellent sensitivity and specificity, enabling accurate and reliable detection of ErbB-4 phosphorylated at Tyr1284 in complex biological samples.

The ErbB-4(Phospho Tyr1284) Polyclonal Antibody is supplied as a liquid formulation, ready for immediate use. It is provided in a convenient size and concentration, ensuring cost-effective and efficient usage. The antibody is also compatible with a wide range of experimental conditions and can be used in both basic research and clinical applications.

With its exceptional performance and reliability, the ErbB-4(Phospho Tyr1284) Polyclonal Antibody is an indispensable tool for researchers and scientists studying ErbB-4 signaling pathways and its implications in various diseases.