ERCC1 Monoclonal Antibody(1B10)

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein ge

The ERCC1 Monoclonal Antibody (1B10) is a highly specialized and meticulously developed product that serves as an invaluable tool in the field of molecular biology and cancer research. This antibody, derived from the hybridoma clone 1B10, specifically targets and binds to the ERCC1 protein, a key component of the nucleotide excision repair pathway.

With its exceptional specificity and sensitivity, the ERCC1 Monoclonal Antibody (1B10) enables researchers to accurately detect and quantify the expression levels of ERCC1 in various biological samples. This information is crucial in understanding the role of ERCC1 in DNA repair mechanisms and its implications in cancer development and treatment.

The ERCC1 Monoclonal Antibody (1B10) is manufactured using state-of-the-art techniques and undergoes rigorous quality control measures to ensure its reliability and reproducibility. It is supplied in a convenient and ready-to-use format, allowing for seamless integration into laboratory workflows.

Researchers and scientists can confidently rely on the ERCC1 Monoclonal Antibody (1B10) to provide precise and consistent results, facilitating groundbreaking discoveries and advancements in the field of molecular biology and cancer research.