FANCA Polyclonal Antibody

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia.

The FANCA Polyclonal Antibody is a highly specific and sensitive antibody that has been developed for the detection of FANCA protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the N-terminal region of human FANCA protein. The FANCA Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The FANCA protein is a key component of the Fanconi anemia (FA) pathway, which is involved in the repair of DNA damage and the maintenance of genomic stability. Mutations in the FANCA gene are associated with Fanconi anemia, a rare genetic disorder characterized by bone marrow failure, developmental abnormalities, and an increased risk of cancer. The FANCA Polyclonal Antibody can be used to study the role of FANCA in the FA pathway and its potential involvement in the development of cancer.

The FANCA Polyclonal Antibody is supplied as a liquid in phosphate-buffered saline (PBS) containing 0.02% sodium azide as a preservative. The antibody is purified by affinity chromatography and has a concentration of 1 mg/ml. The FANCA Polyclonal Antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. The recommended working dilution for Western blotting is 1:1000, while for immunohistochemistry and immunofluorescence, the recommended dilution is 1:200.

In summary, the FANCA Polyclonal Antibody is a highly specific and sensitive antibody that is ideal for the detection of FANCA protein in various biological samples. This antibody is suitable for use in various applications and can be used to study the role of FANCA in the FA pathway and its potential involvement in the development of cancer.