FEN-1 Polyclonal Antibody

Flap endonuclease 1 encoded by FEN1 removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.

The FEN-1 Polyclonal Antibody is a highly specific and sensitive antibody that has been designed to detect and quantify the expression of FEN-1 protein in various biological samples. This antibody has been extensively validated for its specificity and sensitivity, making it an ideal tool for researchers and scientists working in the field of molecular biology and biochemistry.

The FEN-1 Polyclonal Antibody has been produced using high-quality materials and advanced techniques, ensuring that it provides reliable and reproducible results. It has been purified using a combination of chromatography and immunoglobulin-specific affinity purification, resulting in a highly pure and concentrated antibody.

This antibody has been extensively tested in a variety of applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been shown to be highly specific for FEN-1 protein, with minimal cross-reactivity with other proteins.

The FEN-1 Polyclonal Antibody is available in a range of sizes and formats, making it suitable for a variety of experimental needs. It is supplied as a liquid solution, making it easy to use and store.

Overall, the FEN-1 Polyclonal Antibody is a highly reliable and specific tool for the detection and quantification of FEN-1 protein in various biological samples. Its high sensitivity and specificity make it an ideal choice for researchers and scientists working in the field of molecular biology and biochemistry.