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SKU(재고 관리 코드):LAA471Ra81

FITC-Linked Polyclonal Antibody to Osteocalcin (OC)

FITC-Linked Polyclonal Antibody to Osteocalcin (OC)

Organism species

Western blotting: 0.2-2µg/mL;1:250-2500
Immunohistochemistry: 5-20µg/mL;1:25-100
Immunocytochemistry: 5-20µg/mL;1:25-100
Optimal working dilutions must be determined by end user.

Product No.


Organism Species

Rattus norvegicus (Rat) 


Antibody labeling

Ig Type



Antigen-specific affinity chromatography followed by Protein A affinity chromatography



Original Antibody


Buffer Formulation

PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.





Organism Species More




If the antibody is used in flow cytometry, please check FCM antibodies.


20µl 100µl 200µl 1ml 10ml


The antibody is a rabbit polyclonal antibody raised against OC. It has been selected for its ability to recognize OC in immunohistochemical staining and western blotting.


Western blotting: 0.2-2µg/mL;1:250-2500
Immunohistochemistry: 5-20µg/mL;1:25-100
Immunocytochemistry: 5-20µg/mL;1:25-100
Optimal working dilutions must be determined by end user.


Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.


The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.



Acta Biomaterialia

Surface engineering of titanium with potassium hydroxide and its effects on the growth behavior of mesenchymal stem cells PubMed: 19963080

Annals of RSCB

Biochemical study of the influence of ad type biophytomodulators in healing of bone defects in rats. Analelesnbc: source

Asian-Australasian Association of Animal Societies

Variability of Osteocalcin Status in Chinese Holstein Cattle: Do Phylogeny, Vitamin D or Gene Polymorphisms Matter? Ajas: source


Dyslipidemic high-fat diet affects adversely bone metabolism in mice associated with impaired antioxidant capacity ScienceDirect: S0899900709004717

Experimental Biology and Medicine

Osteogenic activity of silymarin through enhancement of alkaline phosphatase and osteocalcin in osteoblasts and tibia-fractured mice Rsm: source

Archives of Oral Biology

Oxytocin promotes bone formation during the alveolar healing process in old acyclic female rats ScienceDirect: S0003996912001021


Regulation of the differentiation of mesenchymal stem cells in vitro and osteogenesis in vivo by microenvironmental modification of titanium alloy surfaces ScienceDirect: S0142961212000865

Life Sciences

Exendin-4 Increases Bone Mineral Density in Type 2 Diabetic OLETF Rats Potentially Through the Down-Regulation of SOST/Sclerostin in Osteocytes PubMed: 23357248

Romanian Journal of Morphology and Embryology

Serum changes induced by intramedullar experimental administration of bisphosphonates PubMed: 21424089

International Journal of Cardiology

Valvular osteoclasts in calcification and aortic valve stenosis severity PubMed: 23452891

Journal of Physiology and Pharmacology

Postnatal administration of 2-oxoglutaric acid improves articular and growth plate cartilages and bone tissue morphology in pigs prenatally treated with dexamethasone PubMed: 23211309

Journal of Applied Toxicology

Chronic exposure to low concentrations of strontium 90 affects bone physiology but not the hematopoietic system in mice Wiley: Source

Chinese Medicine

Puerarin promotes osteogenesis and inhibits adipogenesis in vitro PubMed: PMC3765709

Nephrology Dialysis Transplantation

Magnesium prevents phosphate-induced calcification in human aortic vascular smooth muscle cells PubMed: PMC3611891

J Anim Physiol Anim Nutr (Berl).

Morphological changes of the cartilage and bone in newborn piglets evoked by experimentally induced glucocorticoid excess during pregnancy Pubmed: 22716040

Journal of Cranio-Maxillofacial Surgery

The use of Tri-Calcium Phosphate (TCP) and stem cells for the regeneration of osteoperiosteal critical-size mandibular bony defects, an in vitro and preclinical study Pubmed: 24485270

Nutr Hosp.

Effect of the “protein diet” and bone tissue. Pubmed: 24483972

International Journal of Cardiology

Valvular osteoclasts in calcification and aortic valve stenosis severity. Pubmed: 23452891

Food Science & Nutrition

Effects and mechanisms of 8-prenylnaringenin on osteoblast MC3T3-E1 and osteoclast-like cells RAW264.7 Onlinelibrary: fsn3.109

Nutricion Hospitalaria

Effect of the “protein diet” and bone tissue Aulamedica: Source

Tissue Eng Part A.

Toward the Development and Characterization of an Easy Handling Sheet-Like Biohybrid Bone Substitute Pubmed:25761235

Basic & Clinical Pharmacology & Toxicology

Treatment with Carnitine Enhances Bone Fracture Healing under Osteoporotic and/or Inflammatory Conditions Wiley:Source

Food Sci Nutr.

Effects and mechanisms of 8‐prenylnaringenin on osteoblast MC3T3‐E1 and osteoclast‐like cells RAW264. 7 Pubmed:Pmc4221832

Journal of Cranio-Maxillofacial Surgery

The use of TriCalcium Phosphate (TCP) and stem cells for the regeneration of osteoperiosteal critical-size mandibular bony defects, an in vitro and preclinical study Pubmed:24485270

Naunyn-Schmiedeberg's Archives of Pharmacology

Treatment with α-lipoic acid enhances the bone healing after femoral fracture model of rats Pubmed:25038619

FEBS Letters

Low-intensity pulsed ultrasound-induced ATP increases bone formation via the P2X7 receptor in osteoblast-like MC3T3-E1 cells Pubmed:25542352

American Diabetes Association

Pathophysiological mechanism of bone loss in type 2 diabetes involves inverse regulation of osteoblast function by PPARγ coactivator-1α and skeletal muscle atrogenes: adiponectin receptor 1 as a potential target for reversing diabetes-induced osteopenia Pubmed:25633418

International Journal of Nanomedicine

Immobilizing osteogenic growth peptide with and without fibronectin on a titanium surface: effects of loading methods on mesenchymal stem cell differentiation Pubmed:25678785

Medical Journal fo the Islamic Republic of Iran

Transplantation of mesenchymal stem cells, recombinant human BMP-2,and their combination in accelerating the union after osteotomy and increasing, the mechanical strength of extracorporeally irradiated femoral autograft in rat models Pubmed:25679008

BioMed Research International

Inhibition of osteoclast activation by phloretin through disturbing αvβ3 integrin-c-Src pathway Pubmed:25834823

Advances in Medical Sciences

The influence of bexarotene, a selective agonist of the retinoid receptor X (RXR), and tazarotene, a selective agonist of the retinoid acid receptor (RAR), on bone metabolism in rats PubMed: 26569440

journal of hard Tissue Biology

Biological Evaluation of a Prototype Material made of Polyglycolic Acid and Hydroxyapatite Article: Jhtb

Bioscience Trends

Products of dentin matrix protein-1 degradation by interleukin-1β-induced matrix metalloproteinase-3 promote proliferation of odontoblastic cells PubMed: 26355224

J Nutr Biochem

Body fat loss induced by calcium in co-supplementation with conjugated linoleic acid is associated with increased expression of bone formation genes in adult mice PubMed: 26454511

Int J Mol Med

Curcumin alleviates glucocorticoid-induced osteoporosis through the regulation of the Wnt signaling pathway PubMed: 26677102

Experimental And Therapeutic Medicine

Antiosteoporotic effect of icariin in ovariectomized rats is mediated via the Wnt/β-catenin pathway Pubmed:27347050

International Journal of Life Sciences Research

Impact of Curcumin and Flaxseed Oil on Bone Turnover in Glucocorticoid-Injected Female Rats profile:303311214

Journal of Alloys and Compounds

Enhanced biocompatible and hemocompatible nano/micro porous surface as a biological scaffold for functionalizational and biointegrated implants science:S0045653516302016


The effects of strength training and raloxifene on bone health in aging ovariectomized rats Pubmed:26812611

Biological Trace Element Research

Effect of Sodium Fluoride on Bone Biomechanical and Histomorphometric Parameters and on Insulin Signalingand Insulin Sensitivity in Ovariectomized Rats. Pubmed:26876375


Comparison of the effect of a standard inclusion level of inorganic zinc to organic form at lowered level on bone development in growing male Ross broiler chickens journalprintahead:87

Annals of Animal Science

Comparison of the Effect of a Standard Inclusion Level of Inorganic Zinc to Organic Form at Lowered Level on Bone Development in Growing Male Ross Broiler Chickens view:87

J Bone Miner Metab

MiR-142-5p promotes bone repair by maintaining osteoblast activity Pubmed:27085967

Protective Effect of Soybean and Mushroom against Glucocorticoid-Induced Osteoporosis in Female Rats :

Journal of Functional Foods

Comparative effects of brown and golden flaxseeds on body composition, inflammation and bone remodelling biomarkers in perimenopausal overweight women S1756464617301561

international journal of molecular sciences

Evidence of the Role of R-Spondin 1 and Its Receptor Lgr4 in the Transmission of Mechanical Stimuli to Biological Signals for Bone Formation. pubmed:28272338

Applied Surface Science

The controlled release of simvastatin from TiO2 nanotubes to promote osteoblast differentiation and inhibit osteoclast resorption S0169433216326861


Noni leaf and black tea enhance bone regeneration in estrogen-deficient rats. pubmed:27908549

Chemico-Biological Interactions

Ginsenosides Rg3 attenuates glucocorticoid-induced osteoporosis through regulating BMP-2/BMPR1A/Runx2 signaling pathway pubmed:27387537

Biomedicine & Pharmacotherapy

Fast and long acting neoflavonoids dalbergin isolated from Dalbergia sissoo heartwood is osteoprotective in ovariectomized model of osteoporosis: Osteoprotective … S0753332216308484

Experimental and Therapeutic Medicine

Serum N-terminal telopeptide of type I collagen as an early marker of fracture nonunion in rabbits. pubmed:28105092

Institute of Pharmacology

Effects of long-term administration of pantoprazole on bone mineral density in young male rats. pubmed:27552060

Indian Journal of Orthopaedics

N-terminal telopeptides of type I collagen and bone mineral density for early diagnosis ofnonunion: An experimental study in rabbits. pubmed:27512225

Biological Trace Element Research

Micromolar Levels of Sodium Fluoride Promote Osteoblast Differentiation Through Runx2 Signaling pubmed:28083749

J Trace Elem Med Biol

Effects of fluoride on insulin signaling and bone metabolism in ovariectomized rats. pubmed:27908407

Mater Sci Eng C Mater Biol Appl.

Synthesis of polypyrrole nanowires with positive effect on MC3T3-E1 cell functions through electrical stimulation. pubmed:27987727

Biomedicine & Pharmacotherapy

Anti-osteoporotic effects of an antidepressant tianeptine on ovariectomized rats S0753332216322752

Biological Trace Element Research

Effect of Dietary Phytase Supplementation on Bone and Hyaline Cartilage Development of Broilers Fed with Organically Complexed Copper in a Cu-Deficient Diet article:10.1007

Revista Brasileira de Ciência Avícola

Effect of Zinc Level and Source (Zinc Oxide Vs. Zinc Glycine) on Bone Mechanical and Geometric Parameters, and Histomorphology in Male Ross 308 Broiler Chicken 10.159:1806-9061-2016-0285

Pharmacological Reports

Oral administration of kaempferol inhibits bone loss in rat model of ovariectomy-induced osteopenia pubmed:29031689

Journal of Bone and Mineral Metabolism

MiR‑142‑5p promotes bone repair by maintaining osteoblast activity pubmed:27085967


A novel osteoporosis model with ascorbic acid deficiency in Akr1A1 gene knockout mice. pubmed:28060768

Journal of Inorganic Biochemistry

Biomimetic fabrication of antibacterial calcium phosphates mediated by polydopamine. pubmed:29049953

Biomedicine & pharmacotherapy

Icaritin induces MC3T3-E1 subclone14 cell differentiation through estrogen receptor-mediated ERK1/2 and p38 signaling activation. pubmed:28742995

Asian Journal of Biomedical and Pharmaceutical Sciences

A Water Extract of Benefiting-Bone Capsule Improves Osteoporosis via Transcriptional and Translational Regulation of Key Factors in Notch and Wnt/β-catenin Signaling Pathways in Ovariectomized Rats ISSN 2249 – 622X

Journal of Materials Chemistry B

Stabilization of Ca-deficient hydroxyapatite in biphasic calcium phosphate ceramics by adding alginate to enhance their biological performances 10.1039/C7TB02620J 

Journal of Cellular Physiology

Osteogenic commitment and differentiation of human mesenchymal stem cells by low-intensity pulsed ultrasound stimulation. pubmed:28621452

Materials Science & Engineering C-Materials for Biological Applications

BMP-2 gene transfection of bone marrow stromal cells to induce osteoblastic differentiation in a rat calvarial defect model Pubmed:30033316

Journal of Functional Foods

Effect of long-term administration of mangiferin from on bone metabolism in ovariectomized rats 10.1016:j.jff.2018.04.048

Journal of Ethnopharmacology

Effects of water extract from epimedium on neuropeptide signaling in an ovariectomized osteoporosis rat model Pubmed:29705515

Life Sciences

Myricetin ameliorates glucocorticoid-induced osteoporosis through the ERK signaling pathway Pubmed:29883721

PLoS One

Subsequent somatic axis and bone tissue metabolism responses to a low-zinc diet with or without phytase inclusion in broiler chickens Pubmed:29373588

Royal Society of Chemistry

Stabilization of Ca-deficient hydroxyapatite in biphasic calcium phosphate ceramics by adding alginate to enhance their biological performances c7tb02620j

Molecular Medicine Reports

Effects of constrained dynamic loading, CKIP‑1 gene knockout and combination stimulations on bone loss caused by mechanical unloading Pubmed:29956799

Journal of Ultrasound in Medicine

A Comparison of 1‐and 3.2‐MHz Low‐Intensity Pulsed Ultrasound on Osteogenesis on Porous Titanium Alloy Scaffolds: An In Vitro and In Vivo Study Pubmed:29781183

Tropical Animal Health and Production

Dietary supplementation for Santa Inês hair ewes on pasture at pre-and postpartum periods: dry matter intake, digestibility, milk production, and mineral metabolism Pubmed:29931604

American Scientific Publishers

Effects of KLD-12/Recombinant Human Bone Morphogenetic Protein-2 Nanofiber Scaffold on the Osteogenic Activity of Rabbit Bone Marrow Mesenchymal Stem Cells 10.1166:jbt.2018.1719

Journal of Materials Chemistry B

Enhanced osteoinductivity of porous biphasic calcium phosphate ceramic beads with high content of strontium incorporated calcium deficient hydroxyapatite Doi: 10.1039/C8TB01554F

International Journal of Clinical and Experimental Medicine

Combined effect of pulsed electromagnetic fields and narrowband ultraviolet B on bone metabolism in glucocorticoid-treated rats


Beta-Cyclodextrin Modified Mesoporous Bioactive Glass Nanoparticles/Silk Fibroin Hybrid Nanofibers as an Implantable Estradiol Delivery System for the Potential … Pubmed: 30255905


In Situ Self-Assembly of Graphene Oxide/Polydopamine/Sr2+ Nanosheets on Titanium Surfaces for Enhanced Osteogenic Differentiation of Mesenchymal Stem Cells Doi: 10.1016/j.carbon.2018.10.081

Experimental Gerontology

The decline of whole-body glucose metabolism in ovariectomized rats Pubmed: 30292771

Tropical Journal of Pharmaceutical Research

Mollugin attenuates glucocorticoid-induced osteoporosis in rats via Akt/P13K pathway

Bone & Joint Research

Transcriptome analysis of osteoblasts in an ovariectomized mouse model in response to physical exercise

Bone Research

NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts Pubmed: 30455992

ACS Applied Materials & Interfaces

Osteoinductivity of porous biphasic calcium phosphate ceramic spheres with nanocrystalline and their efficacy in guiding bone regeneration Pubmed: 30629405


CoCr porous scaffolds manufactured via selective laser melting in orthopedics: Topographical, mechanical, and biological characterization Pubmed: 30689288

Chemico-Biological Interactions

Lead exposure inhibits osteoblastic differentiation and inactivates the canonical Wnt signal and recovery by icaritin in MC3T3-E1 subclone 14 cells Pubmed: 30731080


Effect and mechanism of psoralidin on promoting osteogenesis and inhibiting adipogenesis Doi: 10.1016/j.phymed.2019.152860

Advanced Healthcare Materials

Impact of Hydrogel Elasticity and Adherence on Osteosarcoma Cells and Osteoblasts Pubmed: 30838809

American Journal of Translational Research

Long non-coding RNA SNHG7 promotes the fracture repair through negative modulation of miR-9

Journal of Orthopaedic Surgery and Research

Macrophage inhibits the osteogenesis of fibroblasts in ultrahigh molecular weight polyethylene (UHMWPE) wear particle-induced osteolysis

Toxicol Ind Health

Influence of physical training on markers of bone turnover, mechanical properties, morphological alterations, density and mineral contents in the femur of rats exposed … Pubmed: 30983556

Tropical Journal of Pharmaceutical Research

Methylbenzoxime as a therapeutic agent for glucocorticoid-induced osteoporosis in rats.

medical science monitor

Silent Mating Type Information Regulation 2 Homolog (SIRT1) Influences Osteogenic Proliferation and Differentiation of MC3T3-E1 Cells via Regulation of miR-132 … Pubmed: 30923307

Toxicology and applied pharmacology

Alpha ketoglutarate exerts a pro-osteogenic effect in osteoblast cell lines through activation of JNK and mTOR/S6K1/S6 signaling pathways Pubmed: 31051157

Journal of Innovations in Pharmaceutical and Biological Sciences

Preventive effect of dried plum extract against dexamethasone-induced osteoporosis in male rats through inhibiting cathepsin-K activity, lipogenesis and …


A dual functional bone‐defect‐filling material with sequential antibacterial and osteoinductive properties for infected bone defect repair Pubmed: 31173657


Use of Polyphenol Tannic Acid to Functionalize Titanium with Strontium for Enhancement of Osteoblast Differentiation and Reduction of Osteoclast Activity Pubmed: 31362449

Bulletin of Experimental Biology and Medicine

Laboratory Monitoring of Bone Tissue Remodeling after Augmentation of Impression Intraarticular Fracture with Different Types of Bone Graft Pubmed: 31630302

International Journal of Nanomedicine

Nano-Hydroxyapatite Coating Promotes Porous Calcium Phosphate Ceramic-Induced Osteogenesis Via BMP/Smad Signaling Pathway Pubmed: 31632013

Molecular Therapy-Nucleic Acids

AAV-anti-miR-214 prevents collapse of the femoral head in osteonecrosis by regulating osteoblast and osteoclast activities Pubmed: 31739209

International Journal of Environmental Research and Public Health

Alleviating Effect of α-Lipoic Acid and Magnesium on Cadmium-Induced Inflammatory Processes, Oxidative Stress and Bone Metabolism Disorders in Wistar Rats Pubmed: 31739465


MiR-296 Promotes Osteoblast Differentiation by Upregulating Cbfal Pubmed: 31694033

Brazilian Journal of Medical and Biological Research

Beneficial effects of Cuscuta chinensis extract on glucocorticoid-induced osteoporosis through modulation of RANKL/OPG signals Pubmed: 31826180

Biomedicine & Pharmacotherapy

Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss Pubmed: 31846839

Journal of Bone and Mineral Research

BMP9 reduces bone loss in ovariectomized mice by dual regulation of bone remodeling Pubmed: 31914211


EDTA-Modified 17β-Estradiol-Laden Upconversion Nanocomposite for Bone-Targeted Hormone Replacement Therapy for Osteoporosis Pubmed: 32194868

Journal of Korean Neurosurgical Society

Rutin Improves Bone Histomorphometric Values by Reduction of Osteoclastic Activity in Osteoporosis Mouse Model Induced by Bilateral Ovariectomy Pubmed: 32172552


Positive role of calcium phosphate ceramics regulated inflammation in the osteogenic differentiation of mesenchymal stem cells Pubmed: 32064734


HSP90 inhibitors strengthen extracellular ATP‐stimulated synthesis of interleukin‐6 in osteoblasts: Amplification of p38 MAP kinase Pubmed: 32567086

Cell Death & Disease

QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism Pubmed: 32382069

Molecular Medicine Reports

Neuropeptide Y upregulates Runx2 and osterix and enhances osteogenesis in mouse MC3T3‑E1 cells via an autocrine mechanism Pubmed: 33000198

Food & Function

Comparative study of DHA-enriched phosphatidylcholine and EPA-enriched phosphatidylcholine on ameliorating high bone turnover via regulation of the … Pubmed: 33140795


A Hierarchical Janus Nanofibrous Membrane Combining Direct Osteogenesis and Osteoimmunomodulatory Functions for Advanced Bone Regeneration

Revista Argentina de Clínica Psicológica

Research on the Mechanism of miR-142-5p's Promotion of the Function and Mineralization of Osteoblasts by Down-regulating the Expression of WWP1 Gene


Chemical Engineering Journal

Bioinspired polydopamine/graphene oxide/collagen nanofilms as a controlled release carrier of bioactive substances

Surfaces and Interfaces

In vitro comparison of titanium surface conditioning via boron-compounds and sand-blasting acid-etching

J Bone Miner Res

Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/¦Â©\catenin pathway 33950533

Biochemical Engineering Journal

Studies of osteoblast-like MG-63 cellular proliferation and differentiation with cyclic stretching cell culture system on biomimetic hydrophilic layers modified polydimethylsiloxane substrate

Br J Pharmacol

Andrographolide prevents bone loss via targeting ERRalpha‐regulated metabolic adaption of osteoclastogenesis 34233019


Effects of icariin on the fracture healing in young and old rats and its mechanism 34511043

Evid Based Complement Alternat Med

Gujiansan Ameliorates Avascular Necrosis of the Femoral Head by Regulating Autophagy via the HIF-1α/BNIP3 Pathway 34512780

ACS Appl Mater Interfaces

Spatiotemporal Management of the Osteoimmunomodulation of Fibrous Scaffolds by Loading a Novel Amphiphilic Nanomedicine Pubmed:35311248


Notoginsenoside R1 Promotes Migration, Adhesin, Spreading, and Osteogenic Differentiation of Human Adipose Tissue-Derived Mesenchymal Stromal Cells Pubmed:35684342

Journal of Exercise Science & Fitness

Effects of 8-week High-Intensity Interval Training and Moderate-Intensity Continuous Training on Bone Metabolism in Sedentary Young Females Pubmed:35096081

Journal of Bionic Engineering

Effect of Antibacterial Enoxacin on the Properties of Injectable Nano-hydroxyapatite/Polyurethane Cement for Bone Repairing

Catalog No.

Related products for research use of Rattus norvegicus (Rat) Organism species

Applications (RESEARCH USE ONLY!)


Recombinant Osteocalcin (OC)

Positive Control; Immunogen; SDS-PAGE; WB.


Polyclonal Antibody to Osteocalcin (OC)



FITC-Linked Polyclonal Antibody to Osteocalcin (OC)



Biotin-Linked Polyclonal Antibody to Osteocalcin (OC)



Monoclonal Antibody to Osteocalcin (OC)



ELISA Kit for Osteocalcin (OC)

Enzyme-linked immunosorbent assay for Antigen Detection.


Magnetic Luminex Assay Kit for Osteocalcin (OC) ,etc.

Magnetic Luminex Assay for Antigen Detection.


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