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Cayman

15588

Ganglioside GT1b (bovine) (sodium salt)

Ganglioside GT1b (bovine) (sodium salt)

 

Molecular Formula
Formula Weight
Purity
Formulation(Request formulation change)
  • A lyophilized solid
Solubility(Learn about Variance in Solubility)
  • Chloroform:Methanol (2:1): Soluble
  • Water: Micellar aggregates
Shipping & Storage Information
Storage 
  • -20°C
Shipping
  • Room Temperature in continental US; may vary elsewhere
Stability
  • ≥ 4 years
Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. It binds to the neurotoxins botulinum toxin serotype A (BTxA), BTxA heavy chain, and tetanus toxin with IC50 values of 11, 0.74, and 7.2 μM, respectively.1 Ganglioside GT1b-containing liposomes bind to the major coat protein VP1 from Merkel cell polyomavirus (MCPyV), which has been identified in Merkel cell carcinomas, identifying ganglioside GT1b as a putative MCPyV receptor.2 Ganglioside GT1b decreases production of IL-6, IL-10, IgG, IgM, and IgA in human peripheral blood mononuclear cells (PBMCs) by 31.4, 30.5, 60, 59.5, and 58%, respectively, when used at a concentration of 10 μM.3 This product contains ganglioside GT1b molecular species with variable fatty acyl chain lengths. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1558]

 

 

References & Product Citations
Product Description References

1. Schengrund, C.-L., DasGupta, B.R., and Ringler, N.J. Binding of botulinum and tetanus neurotoxins to ganglioside GT1b and derivatives thereof. J. Neurochem. 57(3), 1024-1032 (1991).

2. Erickson, K.D., Garcea, R.L., and Tsai, B. Ganglioside GT1b is a putative host cell receptor for the Merkel cell polyomavirus. J. Virol. 83(19), 10275-10279 (2009).

3. Kanda, N., and Tamaki, K. Ganglioside GT1b suppresses immunoglobulin production by human peripheral blood mononuclear cells. Immunology 96(4), 628-633 (1999).

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