GAR1 Polyclonal Antibody

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene.

The GAR1 Polyclonal Antibody is a highly specific and sensitive immunological reagent designed for the detection and quantification of GAR1 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of human GAR1 protein. The resulting polyclonal antibody exhibits high affinity and specificity towards GAR1 protein, making it an ideal tool for various applications such as Western blotting, immunohistochemistry, and ELISA.

The GAR1 Polyclonal Antibody is purified using a combination of protein A and peptide affinity chromatography, ensuring high purity and minimal cross-reactivity with other proteins. This antibody has been extensively validated for its specificity and sensitivity, and has been shown to detect endogenous GAR1 protein in various human cell lines and tissues.

The GAR1 Polyclonal Antibody is supplied as a liquid formulation in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative. It is available in various sizes to meet the needs of different applications and experimental designs. This antibody is suitable for use in both research and diagnostic settings, and is an essential tool for studying the function and regulation of GAR1 protein in various biological processes.