GLI2 Polyclonal Antibody

This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B.

The GLI2 Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of GLI2 protein expression in various biological samples. This antibody has been meticulously developed and rigorously validated to ensure optimal performance and reliability.

The GLI2 Polyclonal Antibody exhibits exceptional affinity and selectivity towards GLI2, a key transcription factor involved in the regulation of various cellular processes, including embryonic development, tissue homeostasis, and tumorigenesis. By targeting GLI2, this antibody enables researchers to gain valuable insights into the molecular mechanisms underlying these processes.

This antibody has been extensively tested in a variety of experimental settings, including Western blotting, immunohistochemistry, and immunofluorescence. It consistently demonstrates robust and specific staining, allowing for accurate and reproducible detection of GLI2 protein expression in both cultured cells and tissue sections.

The GLI2 Polyclonal Antibody is manufactured using state-of-the-art techniques and high-quality materials to ensure batch-to-batch consistency and optimal performance. It is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation.

With its exceptional sensitivity and specificity, the GLI2 Polyclonal Antibody is an indispensable tool for researchers studying GLI2 protein expression and its role in various biological processes. Its reliable performance and ease of use make it an ideal choice for both basic research and clinical applications.