GluR-1(Phospho Ser849) Polyclonal Antibody

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

The GluR-1(Phospho Ser849) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of GluR-1 protein phosphorylated at Ser849. This antibody has been rigorously validated for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence.

The GluR-1 protein, a member of the ionotropic glutamate receptor family, plays a crucial role in synaptic plasticity and neuronal excitability. Phosphorylation of GluR-1 at Ser849 has been implicated in the regulation of receptor trafficking and synaptic transmission. Therefore, the ability to accurately measure the levels of phosphorylated GluR-1 is essential for understanding the molecular mechanisms underlying synaptic plasticity and neuronal function.

The GluR-1(Phospho Ser849) Polyclonal Antibody has been developed using high-quality immunogens and state-of-the-art production techniques. It exhibits exceptional specificity towards the phosphorylated form of GluR-1, with minimal cross-reactivity to non-phosphorylated GluR-1 or other related proteins. This ensures reliable and accurate results, allowing for precise quantification of phosphorylated GluR-1 levels in various biological samples.

Furthermore, this antibody demonstrates excellent sensitivity, enabling the detection of low-abundance phosphorylated GluR-1 even in complex biological matrices. Its robust performance and reproducibility make it an ideal choice for both qualitative and quantitative analysis of GluR-1 phosphorylation.

The GluR-1(Phospho Ser849) Polyclonal Antibody is supplied as a ready-to-use solution, eliminating the need for time-consuming and error-prone antibody preparation. It is compatible with a wide range of experimental conditions and can be used with various detection methods, including chemiluminescence and fluorescence.

In summary, the GluR-1(Phospho Ser849) Polyclonal Antibody is a reliable and versatile tool for studying the phosphorylation status of GluR-1 protein. Its high specificity, sensitivity, and ease of use make it an invaluable asset for researchers in the fields of neuroscience, molecular biology, and drug discovery.