GluR4 Polyclonal Antibody

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia.

The GluR4 Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of GluR4 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the C-terminal region of GluR4 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The GluR4 Polyclonal Antibody has been extensively validated for its specificity and sensitivity in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It recognizes a single band of approximately 100 kDa in Western blot analysis of rat brain lysates, which corresponds to the expected molecular weight of GluR4 protein. In addition, the antibody shows strong staining of GluR4 protein in rat brain tissue sections in immunohistochemistry and immunofluorescence assays.

This antibody is an essential tool for researchers studying the function and regulation of GluR4 protein in various physiological and pathological processes, including synaptic plasticity, learning and memory, and neurological disorders. Its high specificity and sensitivity make it an ideal choice for detecting GluR4 protein in complex biological samples, such as brain tissue lysates and cerebrospinal fluid.

In summary, the GluR4 Polyclonal Antibody is a reliable and high-quality antibody that provides accurate and reproducible results in various applications. Its specificity, sensitivity, and versatility make it an indispensable tool for researchers studying GluR4 protein in various biological contexts.