HER2/ErbB2(Phospho-Tyr1196) Rabbit Polyclonal Antibody

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However| it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer| stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways| such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase.

Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported| with the most common allele| Ile654/Ile655| shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers| including breast and ovarian tumors. Alternative splicing results in several additional transcript variants| some encoding d

The HER2/ErbB2(Phospho-Tyr1196) Rabbit Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of HER2/ErbB2 protein phosphorylated at tyrosine 1196. This antibody is produced using high-quality rabbit polyclonal antibodies and is suitable for use in a variety of applications, including Western blotting, immunoprecipitation, and immunohistochemistry.

The HER2/ErbB2 protein is a member of the epidermal growth factor receptor (EGFR) family and is known to play a critical role in the development and progression of various cancers. Phosphorylation of tyrosine 1196 is a key event in the activation of HER2/ErbB2 signaling, making this antibody an essential tool for studying the function of this protein in cancer biology.

This antibody has been rigorously tested for specificity and sensitivity, ensuring reliable and reproducible results. It is supplied in a convenient format, with sufficient quantity for multiple experiments. The HER2/ErbB2(Phospho-Tyr1196) Rabbit Polyclonal Antibody is an essential tool for researchers studying the role of HER2/ErbB2 in cancer biology and is a valuable addition to any laboratory's toolkit.