Histone H2A.Z (Acetyl Lys14) Rabbit Polyclonal Antibody

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin| limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation| DNA repair| DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones| also called histone code| and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin.

May be required for chromosome segregation during cell division.|mass spectrometry:Monoisotopic| not modified PubMed:16457589|PTM:Acetylated on Lys-5| Lys-8 and Lys-12 during interphase. Acetylation disappears at mitosis.|PTM:Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression.|PTM:Not phosphorylated.|Belongs to the histone H2A family.|subunit:The nucleosome is a histone octamer containing two molecules each of H2A| H2B| H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2AFZ forms an heterodimer with H2B. H2AFZ interacts with INCENP.|

Introducing the Histone H2A.Z (Acetyl Lys14) Rabbit Polyclonal Antibody, a cutting-edge scientific tool meticulously designed to facilitate advanced research in the field of epigenetics. This antibody, derived from rabbit polyclonal sources, exhibits exceptional specificity and sensitivity, enabling precise detection and analysis of Histone H2A.Z with acetylated Lysine 14 residue.

Crafted with utmost precision and utilizing state-of-the-art technology, this antibody guarantees reliable and reproducible results, making it an indispensable asset for scientists and researchers alike. Its exceptional affinity towards Histone H2A.Z (Acetyl Lys14) ensures accurate identification and quantification of this crucial epigenetic marker, enabling comprehensive investigations into chromatin remodeling, gene expression regulation, and cellular differentiation.

The Histone H2A.Z (Acetyl Lys14) Rabbit Polyclonal Antibody boasts an extensive range of applications, including chromatin immunoprecipitation (ChIP), immunofluorescence, and western blotting. Its versatility allows for seamless integration into various experimental protocols, empowering researchers to delve deeper into the intricate mechanisms governing epigenetic modifications.

Furthermore, this antibody's robust performance is complemented by its exceptional reliability and consistency, ensuring consistent and reproducible results across multiple experiments. Its high specificity minimizes the risk of cross-reactivity, guaranteeing accurate and precise detection of Histone H2A.Z (Acetyl Lys14) in complex biological samples.

In summary, the Histone H2A.Z (Acetyl Lys14) Rabbit Polyclonal Antibody represents a breakthrough in epigenetic research, offering unparalleled specificity, sensitivity, and reliability. With its broad range of applications and exceptional performance, this antibody is an indispensable tool for scientists and researchers seeking to unravel the intricate complexities of chromatin dynamics and gene regulation.