Histone H2B (Acetyl Lys121) Rabbit Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A| H2B| H3| and H4).

The chromatin fiber is further compacted through the interaction of a linker histone| H1| with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.

The Histone H3 (Tri Methyl Lys37) Rabbit Polyclonal Antibody is a highly specific and sensitive antibody designed for the detection of Histone H3 protein in various biological samples. This antibody is produced by immunizing rabbits with a synthetic peptide corresponding to the Tri Methyl Lys37 region of Histone H3 protein. The antibody has been purified using protein A affinity chromatography and is supplied as a liquid solution in phosphate-buffered saline (PBS) with 0.02% sodium azide as a preservative.

The Histone H3 (Tri Methyl Lys37) Rabbit Polyclonal Antibody is suitable for use in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It has been validated for use in human, mouse, and rat samples and has been shown to exhibit high specificity and sensitivity in detecting Histone H3 protein.

This antibody is an essential tool for researchers studying epigenetics and chromatin biology. It enables the detection and quantification of Histone H3 protein modifications, which play a critical role in gene expression regulation, DNA replication, and repair. The Histone H3 (Tri Methyl Lys37) Rabbit Polyclonal Antibody is a reliable and high-quality reagent that can help advance research in these fields.