Histone H2B (Acetyl Lys24/25) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.

The Histone H2B (Acetyl Lys24/25) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of acetylated lysine residues at positions 24 and 25 on the histone H2B protein. This antibody is produced through a rigorous process of immunization and purification, ensuring high affinity and specificity for the target epitope.

Histone H2B is a crucial component of the nucleosome, playing a vital role in chromatin structure and gene regulation. Acetylation of lysine residues on histone proteins has been widely implicated in the modulation of chromatin accessibility and transcriptional activity. The acetylation of lysine 24 and 25 on histone H2B has been specifically associated with gene activation and is therefore of great interest in the field of epigenetics.

The Histone H2B (Acetyl Lys24/25) Polyclonal Antibody has been extensively validated for various applications, including Western blotting, immunoprecipitation, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of acetylated histone H2B in various biological samples.

This antibody is supplied as a purified and concentrated solution, ensuring optimal performance and ease of use. It is suitable for both research and diagnostic purposes, providing valuable insights into the epigenetic regulation of gene expression.

In summary, the Histone H2B (Acetyl Lys24/25) Polyclonal Antibody is a highly reliable and specific tool for the detection and analysis of acetylated lysine residues on histone H2B. Its exceptional sensitivity and specificity make it an invaluable asset for researchers and clinicians studying epigenetic modifications and their impact on gene regulation.