Histone H2B (Tri Methyl Lys43) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST1H2BA is intronless and encodes a replication-dependent histone that is a testis/sperm-specific member of the histone H2B family. Transcripts from HIST1H2BA contain a palindromic termination element.

The Histone H2B (Tri Methyl Lys43) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of histone H2B protein modifications. This antibody is produced using advanced techniques and rigorous quality control measures to ensure optimal performance and reliability.

Histone H2B is a key component of nucleosomes, which are the basic units of chromatin structure. It plays a crucial role in regulating gene expression and chromatin organization. The tri-methylation of lysine 43 on histone H2B has been implicated in various biological processes, including transcriptional activation and DNA repair.

This polyclonal antibody is raised against a synthetic peptide corresponding to the tri-methylated lysine 43 region of histone H2B. It has been extensively validated for specificity and sensitivity in various experimental applications, including Western blotting, immunohistochemistry, and chromatin immunoprecipitation.

With its high affinity and specificity, this antibody enables accurate and reliable detection of histone H2B tri-methylation at lysine 43, allowing researchers to gain valuable insights into the epigenetic regulation of gene expression and chromatin dynamics. It is an essential tool for studying various biological processes and diseases, including cancer, developmental disorders, and neurodegenerative diseases.

The Histone H2B (Tri Methyl Lys43) Polyclonal Antibody is supplied in a convenient and ready-to-use format, ensuring ease of use and consistent results. It is available in various sizes to meet the specific needs of different experimental setups.

Choose this high-quality antibody to enhance your research and advance your understanding of histone modifications and their role in cellular processes.