Histone H4 (Acetyl Lys16) Polyclonal Antibody

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST4H4 is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from HIST4H4 lack polyA tails; instead, they contain a palindromic termination element.

The Histone H4 (Acetyl Lys16) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and analysis of acetylated Lysine 16 on Histone H4. This antibody is produced using advanced immunization techniques, ensuring high affinity and specificity towards the target antigen.

Histone H4 is a crucial component of chromatin structure and plays a vital role in gene regulation and DNA packaging. Acetylation of Lysine 16 on Histone H4 has been implicated in various biological processes, including transcriptional activation and chromatin remodeling. Therefore, the detection and quantification of acetylated Lysine 16 on Histone H4 are of great importance in understanding the epigenetic regulation of gene expression.

The Histone H4 (Acetyl Lys16) Polyclonal Antibody exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of acetylated Lysine 16 on Histone H4 in various experimental applications, such as Western blotting, immunoprecipitation, and immunofluorescence. This antibody has been extensively validated and optimized to ensure consistent and reproducible results.

With its superior performance and reliability, the Histone H4 (Acetyl Lys16) Polyclonal Antibody is an indispensable tool for researchers studying epigenetics, chromatin biology, and gene regulation. Its high specificity and sensitivity make it an ideal choice for both basic research and clinical applications.