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RayBiotech
SKU(재고 관리 코드):ELH-TGFb1-1
Human TGF-beta 1 ELISA Kit
Human TGF-beta 1 ELISA Kit
Product Description
Specifications
| Size | 1 Plate Kit, 2 Plate Kit, 5 Plate Kit, 10 Plate Kit |
|---|---|
| Species | Human |
| Accession Number | P01137 |
| Gene Symbols | TGFB1|TGFB |
| Gene Id | 7040 |
| Protein Name / Synonyms | Transforming growth factor beta-1 (TGF-beta-1) [Cleaved into: Latency-associated peptide (LAP)] |
| Quantitative/Semi-Quantitative | Quantitative |
| Specificity | This ELISA kit shows no cross-reactivity with any of the cytokines tested: Human ANG, CD23, Eotaxin, GCSF, GM-CSF, GRO-alpha, GRO-beta, GRO-gamma, I-309, IFN-gamma, IL-1 alpha, IL-1 beta, IL-3, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p40), IL-12 (p70), IL-15, IL-16, IP-10, MCP-1, MCP-2, MCP-3, MCP-4, MCSF, MIG, MIP-1alpha, MIP-1beta, NAP-2, PDGF, PF-4, PARC, SCF, SDF-1alpha, TIMP-1, TIMP-2, TNF-alha, TGF-beta 2, TGF-beta 3, VEGF. |
| Compatible Sample Types | Cell Culture Supernatants, Plasma, Serum |
| Solid Support | 96-well Microplate |
| Method Of Detection | Colorimetric |
| Design Principle | Sandwich-based |
| Sensitivity |
18 pg/ml
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| Detection Range | 18 pg/ml - 4000 pg/ml |
| Recommended Dilution (Serum/Plasma) | 20 fold after treatment (see activation steps on page 6) |
| Estimated Lead Time | 1-2 business days |
| Storage | ≤-20°C |
Target Background
Transforming growth factor β1 (TGFB1) is a cytokine that has an important role in a number of different cellular functions, such as, proliferation, differentiation, chemotaxis, apoptosis and tumor suppression. It plays a crucial role in bone metabolism where is acts as a coupling factor between bone resorption and bone formation. TGFB1 has affinity to TGFB1, 2 and 3 receptors. Downstream TGFB1 signaling activates Smad proteins, mitogen-activated protein kinases and protein kinase B. Mutations in the gene can result in Camurati-Engelmann disease (characterized by increased bone density). Numerous cancer cells are also known to secrete increased levels of TGFB1.
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