IκB-alpha(Phospho Tyr42) Polyclonal Antibody

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

The IκB-alpha(Phospho Tyr42) Polyclonal Antibody is a highly specific and sensitive tool for the detection and quantification of IκB-alpha protein phosphorylated at Tyr42. This antibody has been rigorously validated for use in various applications, including Western blotting, immunoprecipitation, and immunohistochemistry.

IκB-alpha is a key regulator of the nuclear factor kappa B (NF-κB) signaling pathway, which plays a critical role in the regulation of immune responses, inflammation, and cell survival. Phosphorylation of IκB-alpha at Tyr42 is known to modulate its function and stability, thereby influencing NF-κB activation.

The IκB-alpha(Phospho Tyr42) Polyclonal Antibody has been developed using state-of-the-art techniques to ensure high specificity and sensitivity. It has been extensively tested and validated to provide reliable and reproducible results. This antibody exhibits minimal cross-reactivity with non-phosphorylated IκB-alpha and other related proteins, ensuring accurate detection and quantification of phosphorylated IκB-alpha.

With its superior performance and versatility, the IκB-alpha(Phospho Tyr42) Polyclonal Antibody is an indispensable tool for researchers studying the NF-κB signaling pathway and its role in various biological processes. Its high affinity and specificity make it ideal for both qualitative and quantitative analysis of phosphorylated IκB-alpha in various sample types, including cell lysates, tissue extracts, and cultured cells.

Order the IκB-alpha(Phospho Tyr42) Polyclonal Antibody today and unlock new insights into the intricate mechanisms of NF-κB signaling and its implications in disease pathogenesis.