IκB-beta(Phospho Ser23) Polyclonal Antibody

The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.

The IκB-beta(Phospho Ser23) Polyclonal Antibody is a highly specific and sensitive tool designed for the detection and quantification of IκB-beta protein phosphorylated at Ser23. This antibody is produced using advanced polyclonal antibody technology, ensuring high affinity and specificity for the target protein.

IκB-beta is a crucial regulator of the nuclear factor kappa B (NF-κB) signaling pathway, which plays a pivotal role in various cellular processes, including inflammation, immune response, and cell survival. Phosphorylation of IκB-beta at Ser23 is a key post-translational modification that leads to its degradation, allowing NF-κB to translocate to the nucleus and activate gene expression.

The IκB-beta(Phospho Ser23) Polyclonal Antibody has been extensively validated for its performance in various applications, including Western blotting, immunohistochemistry, and immunofluorescence. It exhibits exceptional sensitivity and specificity, enabling accurate and reliable detection of phosphorylated IκB-beta in complex biological samples.

This antibody is supplied as a liquid formulation, ready for immediate use. It has been optimized for use in a wide range of species, including human, mouse, and rat, making it a versatile tool for researchers in diverse fields of study.

With its superior performance and reliability, the IκB-beta(Phospho Ser23) Polyclonal Antibody is an essential tool for investigating the role of IκB-beta phosphorylation in NF-κB signaling and its implications in various physiological and pathological processes.